Tissue factor pathway inhibitor 2 (TFPI2)
Homo sapiens — UniProt P48307
Data last refreshed: (UniProt release unknown)
Key facts
Tissue factor pathway inhibitor 2 (TFPI2) is a protein from Homo sapiens identified by UniProt accession P48307, 235 residues long. MolForge cross-references it against 0 known binders and 234 disease associations.
- UniProt accession: P48307; gene symbol TFPI2.
- Organism: Homo sapiens.
- Length: 235 amino acids.
- Top disease associations (Open Targets): neoplasm, breast cancer and oral squamous cell carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Tissue factor pathway inhibitor 2 |
|---|---|
| UniProt accession | P48307 |
| Gene | TFPI2 |
| Organism | Homo sapiens |
| Length | 235 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (234)
Diseases linked to this target (Open Targets).
- neoplasm · score 0.11
- breast cancer · score 0.10
- oral squamous cell carcinoma · score 0.10
- preeclampsia · score 0.09
- attention deficit hyperactivity disorder · score 0.09
- pancreatic carcinoma · score 0.09
- small cell lung carcinoma · score 0.08
- heart rate · score 0.07
- schizophrenia 15 · score 0.07
- attention deficit-hyperactivity disorder 8 · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-P48307-F1 | alphafold | PREDICTED | 84.00 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for P48307.
Amino-acid sequence (235 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TFPI2?
The strongest Open Targets associations for TFPI2 are neoplasm, breast cancer, oral squamous cell carcinoma, preeclampsia and attention deficit hyperactivity disorder.
How long is the TFPI2 protein?
The Homo sapiens TFPI2 protein (UniProt P48307) is 235 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB P48307 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB P48307 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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