Transcription factor SOX-2 (SOX2)
Homo sapiens — UniProt P48431
Data last refreshed: (UniProt release unknown)
Key facts
Transcription factor SOX-2 (SOX2) is a protein from Homo sapiens identified by UniProt accession P48431, 317 residues long. MolForge cross-references it against 0 known binders and 1,032 disease associations.
- UniProt accession: P48431; gene symbol SOX2.
- Organism: Homo sapiens.
- Length: 317 amino acids.
- Top disease associations (Open Targets): Anophthalmia/microphthalmia - esophageal atresia, anophthalmia/microphthalmia-esophageal atresia syndrome and Jackson-Weiss syndrome.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transcription factor SOX-2 |
|---|---|
| UniProt accession | P48431 |
| Gene | SOX2 |
| Organism | Homo sapiens |
| Length | 317 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (1032)
Diseases linked to this target (Open Targets).
- Anophthalmia/microphthalmia - esophageal atresia · score 0.81
- anophthalmia/microphthalmia-esophageal atresia syndrome · score 0.81
- Jackson-Weiss syndrome · score 0.61
- neurodegenerative disease · score 0.55
- Septo-optic dysplasia · score 0.46
- genetic disorder · score 0.44
- Anophthalmia · score 0.43
- refractive error measurement · score 0.43
- cataract · score 0.41
- risk-taking behaviour · score 0.41
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-P48431-F1 | alphafold | PREDICTED | 59.83 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for P48431.
Amino-acid sequence (317 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SOX2?
The strongest Open Targets associations for SOX2 are Anophthalmia/microphthalmia - esophageal atresia, anophthalmia/microphthalmia-esophageal atresia syndrome, Jackson-Weiss syndrome, neurodegenerative disease and Septo-optic dysplasia.
How long is the SOX2 protein?
The Homo sapiens SOX2 protein (UniProt P48431) is 317 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB P48431 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB P48431 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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