Transcription factor SOX-9 (SOX9)
Homo sapiens — UniProt P48436
Data last refreshed: (UniProt release unknown)
Key facts
Transcription factor SOX-9 (SOX9) is a protein from Homo sapiens identified by UniProt accession P48436, 509 residues long. MolForge cross-references it against 0 known binders and 1,051 disease associations.
- UniProt accession: P48436; gene symbol SOX9.
- Organism: Homo sapiens.
- Length: 509 amino acids.
- Top disease associations (Open Targets): campomelic dysplasia, isolated Pierre-Robin syndrome and Pierre-Robin sequence.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transcription factor SOX-9 |
|---|---|
| UniProt accession | P48436 |
| Gene | SOX9 |
| Organism | Homo sapiens |
| Length | 509 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (1051)
Diseases linked to this target (Open Targets).
- campomelic dysplasia · score 0.86
- isolated Pierre-Robin syndrome · score 0.60
- Pierre-Robin sequence · score 0.56
- neurodegenerative disease · score 0.55
- genetic disorder · score 0.50
- colorectal adenocarcinoma · score 0.49
- connective tissue disease · score 0.47
- body height · score 0.44
- nose morphology measurement · score 0.42
- vital capacity · score 0.41
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-P48436-F1 | alphafold | PREDICTED | 55.97 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for P48436.
Amino-acid sequence (509 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SOX9?
The strongest Open Targets associations for SOX9 are campomelic dysplasia, isolated Pierre-Robin syndrome, Pierre-Robin sequence, neurodegenerative disease and genetic disorder.
How long is the SOX9 protein?
The Homo sapiens SOX9 protein (UniProt P48436) is 509 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB P48436 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB P48436 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.