Sodium/hydrogen exchanger 3 (SLC9A3)
Homo sapiens — UniProt P48764
Data last refreshed: (UniProt release unknown)
Key facts
Sodium/hydrogen exchanger 3 (SLC9A3) is a protein from Homo sapiens identified by UniProt accession P48764, 834 residues long. MolForge cross-references it against 1 known binders and 270 disease associations.
- UniProt accession: P48764; gene symbol SLC9A3.
- Organism: Homo sapiens.
- Length: 834 amino acids.
- Approved drugs acting on it (DrugCentral): Tenapanor.
- Top disease associations (Open Targets): congenital sodium diarrhea, irritable bowel syndrome and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Sodium/hydrogen exchanger 3 |
|---|---|
| UniProt accession | P48764 |
| Gene | SLC9A3 |
| Organism | Homo sapiens |
| Length | 834 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). Approved drug exists
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Approved drugs acting on this target (1)
Approved drugs whose DrugCentral mechanism of action is this protein, most potent first.
Disease associations (270)
Diseases linked to this target (Open Targets).
- congenital sodium diarrhea · score 0.61
- irritable bowel syndrome · score 0.57
- neurodegenerative disease · score 0.47
- constipation disorder · score 0.46
- hyperphosphatemia · score 0.39
- age-related macular degeneration · score 0.38
- cystic fibrosis · score 0.38
- Constipation · score 0.37
- primary hyperoxaluria · score 0.37
- autism spectrum disorder · score 0.33
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-P48764-F1 | alphafold | PREDICTED | 65.96 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for P48764.
Amino-acid sequence (834 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which approved drugs target SLC9A3?
DrugCentral lists 1 approved drug whose mechanism of action is SLC9A3: Tenapanor.
Which diseases are associated with SLC9A3?
The strongest Open Targets associations for SLC9A3 are congenital sodium diarrhea, irritable bowel syndrome, neurodegenerative disease, constipation disorder and hyperphosphatemia.
How long is the SLC9A3 protein?
The Homo sapiens SLC9A3 protein (UniProt P48764) is 834 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB P48764 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB P48764 — predicted 3D structure (CC BY 4.0)
- DrugCentral — approved drugs and mechanism-of-action links (CC BY-SA 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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