Kunitz-type protease inhibitor 3 (SPINT3)
Homo sapiens — UniProt P49223
Data last refreshed: (UniProt release unknown)
Key facts
Kunitz-type protease inhibitor 3 (SPINT3) is a protein from Homo sapiens identified by UniProt accession P49223, 89 residues long. MolForge cross-references it against 0 known binders and 4 disease associations.
- UniProt accession: P49223; gene symbol SPINT3.
- Organism: Homo sapiens.
- Length: 89 amino acids.
- Top disease associations (Open Targets): blood protein measurement, bladder exstrophy and psoriasis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Kunitz-type protease inhibitor 3 |
|---|---|
| UniProt accession | P49223 |
| Gene | SPINT3 |
| Organism | Homo sapiens |
| Length | 89 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (4)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.35
- bladder exstrophy · score 0.12
- psoriasis · score 0.02
- glioma · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-P49223-F1 | alphafold | PREDICTED | 93.18 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for P49223.
Amino-acid sequence (89 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SPINT3?
The strongest Open Targets associations for SPINT3 are blood protein measurement, bladder exstrophy, psoriasis and glioma.
How long is the SPINT3 protein?
The Homo sapiens SPINT3 protein (UniProt P49223) is 89 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB P49223 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB P49223 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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