Alpha-tocopherol transfer protein (TTPA)

About Alpha-tocopherol transfer protein

Alpha-tocopherol transfer protein (TTPA) is a protein from Homo sapiens identified by UniProt accession P49638, 278 residues long. MolForge cross-references it against 0 known binders and 153 disease associations.

Target properties

Protein name	Alpha-tocopherol transfer protein
UniProt accession	P49638
Gene	TTPA
Organism	Homo sapiens
Length	278 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (2)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (153)

Diseases linked to this target (Open Targets).

Ataxia with vitamin E deficiency · score 0.82
familial isolated deficiency of vitamin E · score 0.80
hereditary ataxia · score 0.46
Abnormal central motor function · score 0.27
blood protein measurement · score 0.24
calcium measurement · score 0.22
diet measurement · score 0.19
genetic disorder · score 0.19
C-reactive protein measurement · score 0.09
Female infertility due to fertilization defect · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P49638-F1	alphafold	PREDICTED	94.15	—

Amino-acid sequence (278 residues)

MAEARSQPSA GPQLNALPDH SPLLQPGLAA LRRRAREAGV PLAPLPLTDS FLLRFLRARD FDLDLAWRLL KNYYKWRAEC PEISADLHPR SIIGLLKAGY HGVLRSRDPT GSKVLIYRIA HWDPKVFTAY DVFRVSLITS ELIVQEVETQ RNGIKAIFDL EGWQFSHAFQ ITPSVAKKIA AVLTDSFPLK VRGIHLINEP VIFHAVFSMI KPFLTEKIKE RIHMHGNNYK QSLLQHFPDI LPLEYGGEEF SMEDICQEWT NFIMKSEDYL SSISESIQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards