Sperm mitochondrial-associated cysteine-rich protein (SMCP)
Homo sapiens — UniProt P49901
Data last refreshed: (UniProt release unknown)
Key facts
Sperm mitochondrial-associated cysteine-rich protein (SMCP) is a protein from Homo sapiens identified by UniProt accession P49901, 116 residues long. MolForge cross-references it against 0 known binders and 107 disease associations.
- UniProt accession: P49901; gene symbol SMCP.
- Organism: Homo sapiens.
- Length: 116 amino acids.
- Top disease associations (Open Targets): vitamin D deficiency, azoospermia and male infertility with teratozoospermia due to single gene mutation.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Sperm mitochondrial-associated cysteine-rich protein |
|---|---|
| UniProt accession | P49901 |
| Gene | SMCP |
| Organism | Homo sapiens |
| Length | 116 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (107)
Diseases linked to this target (Open Targets).
- vitamin D deficiency · score 0.11
- azoospermia · score 0.08
- male infertility with teratozoospermia due to single gene mutation · score 0.08
- Rare genetic female infertility · score 0.07
- Female infertility due to fertilization defect · score 0.07
- cancer · score 0.07
- spermatogenic failure 55 · score 0.06
- spermatogenic failure 3 · score 0.06
- partial chromosome Y deletion · score 0.06
- spermatogenic failure 7 · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-P49901-F1 | alphafold | PREDICTED | 44.82 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for P49901.
Amino-acid sequence (116 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SMCP?
The strongest Open Targets associations for SMCP are vitamin D deficiency, azoospermia, male infertility with teratozoospermia due to single gene mutation, Rare genetic female infertility and Female infertility due to fertilization defect.
How long is the SMCP protein?
The Homo sapiens SMCP protein (UniProt P49901) is 116 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB P49901 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB P49901 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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