SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 (SMARCA2)
Homo sapiens — UniProt P51531
Data last refreshed: (UniProt release unknown)
Key facts
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 (SMARCA2) is a protein from Homo sapiens identified by UniProt accession P51531, 1590 residues long. MolForge cross-references it against 0 known binders and 316 disease associations.
- UniProt accession: P51531; gene symbol SMARCA2.
- Organism: Homo sapiens.
- Length: 1590 amino acids.
- Top disease associations (Open Targets): intellectual disability - sparse hair - brachydactyly, intellectual disability-sparse hair-brachydactyly syndrome and blepharophimosis-impaired intellectual development syndrome.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 |
|---|---|
| UniProt accession | P51531 |
| Gene | SMARCA2 |
| Organism | Homo sapiens |
| Length | 1590 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (316)
Diseases linked to this target (Open Targets).
- intellectual disability - sparse hair - brachydactyly · score 0.85
- intellectual disability-sparse hair-brachydactyly syndrome · score 0.82
- blepharophimosis-impaired intellectual development syndrome · score 0.66
- genetic disorder · score 0.50
- Intellectual disability · score 0.50
- schizophrenia · score 0.41
- gut microbiome measurement · score 0.41
- Coffin-Siris syndrome · score 0.41
- salivary gland carcinoma · score 0.37
- sex hormone-binding globulin measurement · score 0.35
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-P51531-F1 | alphafold | PREDICTED | 65.09 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for P51531.
Amino-acid sequence (1590 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SMARCA2?
The strongest Open Targets associations for SMARCA2 are intellectual disability - sparse hair - brachydactyly, intellectual disability-sparse hair-brachydactyly syndrome, blepharophimosis-impaired intellectual development syndrome, genetic disorder and Intellectual disability.
How long is the SMARCA2 protein?
The Homo sapiens SMARCA2 protein (UniProt P51531) is 1590 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB P51531 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB P51531 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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