Cationic amino acid transporter 2 (SLC7A2)
Homo sapiens — UniProt P52569
Data last refreshed: (UniProt release unknown)
Key facts
Cationic amino acid transporter 2 (SLC7A2) is a protein from Homo sapiens identified by UniProt accession P52569, 658 residues long. MolForge cross-references it against 0 known binders and 120 disease associations.
- UniProt accession: P52569; gene symbol SLC7A2.
- Organism: Homo sapiens.
- Length: 658 amino acids.
- Target class: Transporter.
- Top disease associations (Open Targets): diastolic blood pressure, amino acid measurement and L-arginine measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Cationic amino acid transporter 2 |
|---|---|
| UniProt accession | P52569 |
| Gene | SLC7A2 |
| Organism | Homo sapiens |
| Length | 658 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | Transporter (inferred from UniProt keywords / EC) |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (120)
Diseases linked to this target (Open Targets).
- diastolic blood pressure · score 0.28
- amino acid measurement · score 0.28
- L-arginine measurement · score 0.26
- neurodegenerative disease · score 0.26
- ornithine measurement · score 0.21
- IGF-1 measurement · score 0.14
- myoepithelial tumor · score 0.11
- neoplasm · score 0.10
- hepatocellular carcinoma · score 0.09
- non-small cell lung carcinoma · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-P52569-F1 | alphafold | PREDICTED | 81.40 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for P52569.
Amino-acid sequence (658 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SLC7A2?
The strongest Open Targets associations for SLC7A2 are diastolic blood pressure, amino acid measurement, L-arginine measurement, neurodegenerative disease and ornithine measurement.
How long is the SLC7A2 protein?
The Homo sapiens SLC7A2 protein (UniProt P52569) is 658 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB P52569 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB P52569 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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