Spermine synthase (SMS)
Homo sapiens — UniProt P52788
Data last refreshed: (UniProt release unknown)
Key facts
Spermine synthase (SMS) is a protein from Homo sapiens identified by UniProt accession P52788, 366 residues long. MolForge cross-references it against 0 known binders and 149 disease associations.
- UniProt accession: P52788; gene symbol SMS.
- Organism: Homo sapiens.
- Length: 366 amino acids.
- Top disease associations (Open Targets): syndromic X-linked intellectual disability Snyder type, X-linked intellectual disability, Snyder type and genetic disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Spermine synthase |
|---|---|
| UniProt accession | P52788 |
| Gene | SMS |
| Organism | Homo sapiens |
| Length | 366 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (149)
Diseases linked to this target (Open Targets).
- syndromic X-linked intellectual disability Snyder type · score 0.80
- X-linked intellectual disability, Snyder type · score 0.79
- genetic disorder · score 0.46
- congenital adrenal hyperplasia · score 0.34
- neuroinflammatory disorder · score 0.34
- Intellectual disability · score 0.33
- neurodegenerative disease · score 0.33
- Smith-Magenis syndrome · score 0.27
- azoospermia · score 0.09
- Male infertility with spermatogenesis disorder due to single gene mutation · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-P52788-F1 | alphafold | PREDICTED | 94.83 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for P52788.
Amino-acid sequence (366 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SMS?
The strongest Open Targets associations for SMS are syndromic X-linked intellectual disability Snyder type, X-linked intellectual disability, Snyder type, genetic disorder, congenital adrenal hyperplasia and neuroinflammatory disorder.
How long is the SMS protein?
The Homo sapiens SMS protein (UniProt P52788) is 366 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB P52788 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB P52788 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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