About Serine/threonine-protein kinase PLK1
Serine/threonine-protein kinase PLK1 (PLK1) is a protein
from Homo sapiens identified by UniProt accession
P53350, 603 residues long.
MolForge cross-references it against 0 known binders and
420 disease associations.
Target properties
| Protein name | Serine/threonine-protein kinase PLK1 |
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| UniProt accession | P53350 |
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| Gene | PLK1 |
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| Organism | Homo sapiens |
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| Length | 603 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (8)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (420)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.54
- Parkinson disease · score 0.53
- lysosomal storage disease · score 0.53
- multiple sclerosis · score 0.53
- Alzheimer disease · score 0.53
- mean corpuscular volume · score 0.44
- Microcephaly · score 0.37
- epilepsy · score 0.37
- Intellectual disability · score 0.37
- microcephaly · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P53350-F1 | alphafold | PREDICTED | 84.03 | — |
Amino-acid sequence (603 residues)
MSAAVTAGKL ARAPADPGKA GVPGVAAPGA PAAAPPAKEI PEVLVDPRSR RRYVRGRFLG KGGFAKCFEI SDADTKEVFA GKIVPKSLLL KPHQREKMSM EISIHRSLAH QHVVGFHGFF EDNDFVFVVL ELCRRRSLLE LHKRRKALTE PEARYYLRQI VLGCQYLHRN RVIHRDLKLG NLFLNEDLEV KIGDFGLATK VEYDGERKKT LCGTPNYIAP EVLSKKGHSF EVDVWSIGCI MYTLLVGKPP FETSCLKETY LRIKKNEYSI PKHINPVAAS LIQKMLQTDP TARPTINELL NDEFFTSGYI PARLPITCLT IPPRFSIAPS SLDPSNRKPL TVLNKGLENP LPERPREKEE PVVRETGEVV DCHLSDMLQQ LHSVNASKPS ERGLVRQEEA EDPACIPIFW VSKWVDYSDK YGLGYQLCDN SVGVLFNDST RLILYNDGDS LQYIERDGTE SYLTVSSHPN SLMKKITLLK YFRNYMSEHL LKAGANITPR EGDELARLPY LRTWFRTRSA IILHLSNGSV QINFFQDHTK LILCPLMAAV TYIDEKRDFR TYRLSLLEEY GCCKELASRL RYARTMVDKL LSSRSASNRL KAS
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