Smoothelin (SMTN)
Homo sapiens — UniProt P53814
Data last refreshed: (UniProt release unknown)
Key facts
Smoothelin (SMTN) is a protein from Homo sapiens identified by UniProt accession P53814, 917 residues long. MolForge cross-references it against 0 known binders and 99 disease associations.
- UniProt accession: P53814; gene symbol SMTN.
- Organism: Homo sapiens.
- Length: 917 amino acids.
- Top disease associations (Open Targets): BMI-adjusted waist circumference, diet measurement and FEV/FVC ratio.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Smoothelin |
|---|---|
| UniProt accession | P53814 |
| Gene | SMTN |
| Organism | Homo sapiens |
| Length | 917 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (99)
Diseases linked to this target (Open Targets).
- BMI-adjusted waist circumference · score 0.21
- diet measurement · score 0.17
- FEV/FVC ratio · score 0.15
- forced expiratory volume · score 0.14
- mean corpuscular volume · score 0.10
- dilated cardiomyopathy 1I · score 0.05
- cardiomyopathy, familial hypertrophic, 30, atrial · score 0.04
- Autosomal recessive early-onset inflammatory bowel disease · score 0.04
- hypertrophic cardiomyopathy · score 0.04
- familial visceral myopathy · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-P53814-F1 | alphafold | PREDICTED | 58.98 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for P53814.
Amino-acid sequence (917 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SMTN?
The strongest Open Targets associations for SMTN are BMI-adjusted waist circumference, diet measurement, FEV/FVC ratio, forced expiratory volume and mean corpuscular volume.
How long is the SMTN protein?
The Homo sapiens SMTN protein (UniProt P53814) is 917 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB P53814 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB P53814 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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