Secreted Ly-6/uPAR-related protein 1 (SLURP1)
Homo sapiens — UniProt P55000
Data last refreshed: (UniProt release unknown)
Key facts
Secreted Ly-6/uPAR-related protein 1 (SLURP1) is a protein from Homo sapiens identified by UniProt accession P55000, 103 residues long. MolForge cross-references it against 0 known binders and 120 disease associations.
- UniProt accession: P55000; gene symbol SLURP1.
- Organism: Homo sapiens.
- Length: 103 amino acids.
- Top disease associations (Open Targets): mal de Meleda, hereditary palmoplantar keratoderma, Gamborg-Nielsen type and Palmoplantar keratoderma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Secreted Ly-6/uPAR-related protein 1 |
|---|---|
| UniProt accession | P55000 |
| Gene | SLURP1 |
| Organism | Homo sapiens |
| Length | 103 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (120)
Diseases linked to this target (Open Targets).
- mal de Meleda · score 0.80
- hereditary palmoplantar keratoderma, Gamborg-Nielsen type · score 0.38
- Palmoplantar keratoderma · score 0.37
- diffuse palmoplantar keratoderma · score 0.37
- DNA methylation · score 0.09
- neoplasm · score 0.09
- total blood protein measurement · score 0.07
- esophageal adenocarcinoma · score 0.06
- benign prostatic hyperplasia · score 0.05
- psoriasis · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-P55000-F1 | alphafold | PREDICTED | 84.20 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for P55000.
Amino-acid sequence (103 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SLURP1?
The strongest Open Targets associations for SLURP1 are mal de Meleda, hereditary palmoplantar keratoderma, Gamborg-Nielsen type, Palmoplantar keratoderma, diffuse palmoplantar keratoderma and DNA methylation.
How long is the SLURP1 protein?
The Homo sapiens SLURP1 protein (UniProt P55000) is 103 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB P55000 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB P55000 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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