Transcription factor SOX-10 (SOX10)
Homo sapiens — UniProt P56693
Data last refreshed: (UniProt release unknown)
Key facts
Transcription factor SOX-10 (SOX10) is a protein from Homo sapiens identified by UniProt accession P56693, 466 residues long. MolForge cross-references it against 0 known binders and 536 disease associations.
- UniProt accession: P56693; gene symbol SOX10.
- Organism: Homo sapiens.
- Length: 466 amino acids.
- Top disease associations (Open Targets): PCWH syndrome, Waardenburg syndrome type 2E and Neurologic Waardenburg-Shah syndrome.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transcription factor SOX-10 |
|---|---|
| UniProt accession | P56693 |
| Gene | SOX10 |
| Organism | Homo sapiens |
| Length | 466 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (536)
Diseases linked to this target (Open Targets).
- PCWH syndrome · score 0.81
- Waardenburg syndrome type 2E · score 0.81
- Neurologic Waardenburg-Shah syndrome · score 0.79
- Waardenburg-Shah syndrome · score 0.74
- Waardenburg syndrome · score 0.64
- deaf blind hypopigmentation syndrome, Yemenite type · score 0.62
- neurodegenerative disease · score 0.53
- Waardenburg syndrome type 1 · score 0.50
- Waardenburg syndrome type 4A · score 0.44
- Rare genetic deafness · score 0.44
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-P56693-F1 | alphafold | PREDICTED | 55.85 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for P56693.
Amino-acid sequence (466 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SOX10?
The strongest Open Targets associations for SOX10 are PCWH syndrome, Waardenburg syndrome type 2E, Neurologic Waardenburg-Shah syndrome, Waardenburg-Shah syndrome and Waardenburg syndrome.
How long is the SOX10 protein?
The Homo sapiens SOX10 protein (UniProt P56693) is 466 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB P56693 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB P56693 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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