About Potassium voltage-gated channel subfamily KQT member 4
Potassium voltage-gated channel subfamily KQT member 4 (KCNQ4) is a protein
from Homo sapiens identified by UniProt accession
P56696, 695 residues long.
MolForge cross-references it against 0 known binders and
181 disease associations.
Target properties
| Protein name | Potassium voltage-gated channel subfamily KQT member 4 |
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| UniProt accession | P56696 |
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| Gene | KCNQ4 |
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| Organism | Homo sapiens |
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| Length | 695 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (4)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (181)
Diseases linked to this target (Open Targets).
- autosomal dominant nonsyndromic hearing loss 2A · score 0.78
- autosomal dominant nonsyndromic hearing loss · score 0.67
- multiple sclerosis · score 0.59
- nonsyndromic genetic hearing loss · score 0.57
- Myasthenia gravis · score 0.57
- epilepsy · score 0.54
- Seizure · score 0.51
- Rare genetic deafness · score 0.51
- small cell carcinoma · score 0.46
- Muscle weakness · score 0.46
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P56696-F1 | alphafold | PREDICTED | 65.25 | — |
Amino-acid sequence (695 residues)
MAEAPPRRLG LGPPPGDAPR AELVALTAVQ SEQGEAGGGG SPRRLGLLGS PLPPGAPLPG PGSGSGSACG QRSSAAHKRY RRLQNWVYNV LERPRGWAFV YHVFIFLLVF SCLVLSVLST IQEHQELANE CLLILEFVMI VVFGLEYIVR VWSAGCCCRY RGWQGRFRFA RKPFCVIDFI VFVASVAVIA AGTQGNIFAT SALRSMRFLQ ILRMVRMDRR GGTWKLLGSV VYAHSKELIT AWYIGFLVLI FASFLVYLAE KDANSDFSSY ADSLWWGTIT LTTIGYGDKT PHTWLGRVLA AGFALLGISF FALPAGILGS GFALKVQEQH RQKHFEKRRM PAANLIQAAW RLYSTDMSRA YLTATWYYYD SILPSFRELA LLFEHVQRAR NGGLRPLEVR RAPVPDGAPS RYPPVATCHR PGSTSFCPGE SSRMGIKDRI RMGSSQRRTG PSKQHLAPPT MPTSPSSEQV GEATSPTKVQ KSWSFNDRTR FRASLRLKPR TSAEDAPSEE VAEEKSYQCE LTVDDIMPAV KTVIRSIRIL KFLVAKRKFK ETLRPYDVKD VIEQYSAGHL DMLGRIKSLQ TRVDQIVGRG PGDRKAREKG DKGPSDAEVV DEISMMGRVV KVEKQVQSIE HKLDLLLGFY SRCLRSGTSA SLGAVQVPLF DPDITSDYHS PVDHEDISVS AQTLSISRSV STNMD
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