Transcription factor SOX-8 (SOX8)
Homo sapiens — UniProt P57073
Data last refreshed: (UniProt release unknown)
Key facts
Transcription factor SOX-8 (SOX8) is a protein from Homo sapiens identified by UniProt accession P57073, 446 residues long. MolForge cross-references it against 0 known binders and 217 disease associations.
- UniProt accession: P57073; gene symbol SOX8.
- Organism: Homo sapiens.
- Length: 446 amino acids.
- Top disease associations (Open Targets): multiple sclerosis, peak expiratory flow and aortic measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transcription factor SOX-8 |
|---|---|
| UniProt accession | P57073 |
| Gene | SOX8 |
| Organism | Homo sapiens |
| Length | 446 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (217)
Diseases linked to this target (Open Targets).
- multiple sclerosis · score 0.20
- peak expiratory flow · score 0.20
- aortic measurement · score 0.20
- protein measurement · score 0.16
- rhabdomyosarcoma · score 0.15
- testosterone measurement · score 0.15
- 46,XY disorder of sex development · score 0.14
- body height · score 0.13
- electrocardiography · score 0.12
- lean body mass · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-P57073-F1 | alphafold | PREDICTED | 58.12 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for P57073.
Amino-acid sequence (446 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SOX8?
The strongest Open Targets associations for SOX8 are multiple sclerosis, peak expiratory flow, aortic measurement, protein measurement and rhabdomyosarcoma.
How long is the SOX8 protein?
The Homo sapiens SOX8 protein (UniProt P57073) is 446 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB P57073 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB P57073 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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