Sodium/calcium exchanger 3 (SLC8A3)
Homo sapiens — UniProt P57103
Data last refreshed: (UniProt release unknown)
Key facts
Sodium/calcium exchanger 3 (SLC8A3) is a protein from Homo sapiens identified by UniProt accession P57103, 927 residues long. MolForge cross-references it against 0 known binders and 83 disease associations.
- UniProt accession: P57103; gene symbol SLC8A3.
- Organism: Homo sapiens.
- Length: 927 amino acids.
- Top disease associations (Open Targets): body height, mean platelet volume and breast adenocarcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Sodium/calcium exchanger 3 |
|---|---|
| UniProt accession | P57103 |
| Gene | SLC8A3 |
| Organism | Homo sapiens |
| Length | 927 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (83)
Diseases linked to this target (Open Targets).
- body height · score 0.40
- mean platelet volume · score 0.32
- breast adenocarcinoma · score 0.24
- sitting height measurement · score 0.24
- apolipoprotein B measurement · score 0.20
- monocyte count · score 0.18
- pancreatic adenocarcinoma · score 0.14
- prostate carcinoma · score 0.12
- tuberculosis · score 0.12
- prostate cancer · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-P57103-F1 | alphafold | PREDICTED | 76.78 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for P57103.
Amino-acid sequence (927 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SLC8A3?
The strongest Open Targets associations for SLC8A3 are body height, mean platelet volume, breast adenocarcinoma, sitting height measurement and apolipoprotein B measurement.
How long is the SLC8A3 protein?
The Homo sapiens SLC8A3 protein (UniProt P57103) is 927 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB P57103 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB P57103 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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