Serine protease inhibitor Kazal-type 7 (SPINK7)
Homo sapiens — UniProt P58062
Data last refreshed: (UniProt release unknown)
Key facts
Serine protease inhibitor Kazal-type 7 (SPINK7) is a protein from Homo sapiens identified by UniProt accession P58062, 85 residues long. MolForge cross-references it against 0 known binders and 47 disease associations.
- UniProt accession: P58062; gene symbol SPINK7.
- Organism: Homo sapiens.
- Length: 85 amino acids.
- Top disease associations (Open Targets): oral squamous cell carcinoma, neutrophil count and cancer.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Serine protease inhibitor Kazal-type 7 |
|---|---|
| UniProt accession | P58062 |
| Gene | SPINK7 |
| Organism | Homo sapiens |
| Length | 85 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (47)
Diseases linked to this target (Open Targets).
- oral squamous cell carcinoma · score 0.09
- neutrophil count · score 0.08
- cancer · score 0.07
- pulse pressure measurement · score 0.06
- leukocyte count · score 0.06
- Autosomal recessive early-onset inflammatory bowel disease · score 0.04
- esophageal adenocarcinoma · score 0.04
- Crohn's disease · score 0.04
- ulcerative colitis · score 0.04
- inflammatory bowel disease 1 · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-P58062-F1 | alphafold | PREDICTED | 89.86 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for P58062.
Amino-acid sequence (85 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SPINK7?
The strongest Open Targets associations for SPINK7 are oral squamous cell carcinoma, neutrophil count, cancer, pulse pressure measurement and leukocyte count.
How long is the SPINK7 protein?
The Homo sapiens SPINK7 protein (UniProt P58062) is 85 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB P58062 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB P58062 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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