Small integral membrane protein 11 (SMIM11)
Homo sapiens — UniProt P58511
Data last refreshed: (UniProt release unknown)
Key facts
Small integral membrane protein 11 (SMIM11) is a protein from Homo sapiens identified by UniProt accession P58511, 58 residues long. MolForge cross-references it against 0 known binders and 36 disease associations.
- UniProt accession: P58511; gene symbol SMIM11.
- Organism: Homo sapiens.
- Length: 58 amino acids.
- Top disease associations (Open Targets): coronary artery disease, myocardial infarction and FEV/FVC ratio.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Small integral membrane protein 11 |
|---|---|
| UniProt accession | P58511 |
| Gene | SMIM11 |
| Organism | Homo sapiens |
| Length | 58 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (36)
Diseases linked to this target (Open Targets).
- coronary artery disease · score 0.24
- myocardial infarction · score 0.23
- FEV/FVC ratio · score 0.23
- pulse pressure measurement · score 0.20
- migraine disorder · score 0.18
- BMI-adjusted waist-hip ratio · score 0.18
- waist-hip ratio · score 0.18
- angina pectoris · score 0.18
- body height · score 0.17
- BMI-adjusted hip circumference · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-P58511-F1 | alphafold | PREDICTED | 82.58 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for P58511.
Amino-acid sequence (58 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SMIM11?
The strongest Open Targets associations for SMIM11 are coronary artery disease, myocardial infarction, FEV/FVC ratio, pulse pressure measurement and migraine disorder.
How long is the SMIM11 protein?
The Homo sapiens SMIM11 protein (UniProt P58511) is 58 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB P58511 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB P58511 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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