Synaptosomal-associated protein 25 (SNAP25)
Homo sapiens — UniProt P60880
Data last refreshed: (UniProt release unknown)
Key facts
Synaptosomal-associated protein 25 (SNAP25) is a protein from Homo sapiens identified by UniProt accession P60880, 206 residues long. MolForge cross-references it against 3 known binders and 517 disease associations.
- UniProt accession: P60880; gene symbol SNAP25.
- Organism: Homo sapiens.
- Length: 206 amino acids.
- Approved drugs acting on it (DrugCentral): botulinum toxin type A, Letibotulinumtoxina and prabotulinumtoxinA.
- Top disease associations (Open Targets): developmental and epileptic encephalopathy, Congenital myasthenic syndromes and Facial wrinkling.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Synaptosomal-associated protein 25 |
|---|---|
| UniProt accession | P60880 |
| Gene | SNAP25 |
| Organism | Homo sapiens |
| Length | 206 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). Approved drug exists
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Approved drugs acting on this target (3)
Approved drugs whose DrugCentral mechanism of action is this protein, most potent first.
Disease associations (517)
Diseases linked to this target (Open Targets).
- developmental and epileptic encephalopathy · score 0.61
- Congenital myasthenic syndromes · score 0.61
- Facial wrinkling · score 0.59
- migraine disorder · score 0.59
- overactive bladder · score 0.59
- Spasticity · score 0.58
- Torticollis · score 0.58
- skin aging · score 0.58
- Hyperhidrosis · score 0.56
- pain · score 0.56
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-P60880-F1 | alphafold | PREDICTED | 83.37 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for P60880.
Amino-acid sequence (206 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which approved drugs target SNAP25?
DrugCentral lists 3 approved drugs whose mechanism of action is SNAP25: botulinum toxin type A, Letibotulinumtoxina and prabotulinumtoxinA.
Which diseases are associated with SNAP25?
The strongest Open Targets associations for SNAP25 are developmental and epileptic encephalopathy, Congenital myasthenic syndromes, Facial wrinkling, migraine disorder and overactive bladder.
How long is the SNAP25 protein?
The Homo sapiens SNAP25 protein (UniProt P60880) is 206 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB P60880 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB P60880 — predicted 3D structure (CC BY 4.0)
- DrugCentral — approved drugs and mechanism-of-action links (CC BY-SA 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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