Signal peptidase complex subunit 3 (SPCS3)
Homo sapiens — UniProt P61009
Data last refreshed: (UniProt release unknown)
Key facts
Signal peptidase complex subunit 3 (SPCS3) is a protein from Homo sapiens identified by UniProt accession P61009, 180 residues long. MolForge cross-references it against 0 known binders and 28 disease associations.
- UniProt accession: P61009; gene symbol SPCS3.
- Organism: Homo sapiens.
- Length: 180 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, endometrial cancer and electrocardiography.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Signal peptidase complex subunit 3 |
|---|---|
| UniProt accession | P61009 |
| Gene | SPCS3 |
| Organism | Homo sapiens |
| Length | 180 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (28)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.53
- endometrial cancer · score 0.26
- electrocardiography · score 0.23
- serum albumin measurement · score 0.22
- total blood protein measurement · score 0.19
- aspartate aminotransferase measurement · score 0.19
- appendicular lean mass · score 0.16
- Hallux valgus · score 0.14
- intraocular pressure measurement · score 0.09
- brain aneurysm · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-P61009-F1 | alphafold | PREDICTED | 91.79 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for P61009.
Amino-acid sequence (180 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SPCS3?
The strongest Open Targets associations for SPCS3 are neurodegenerative disease, endometrial cancer, electrocardiography, serum albumin measurement and total blood protein measurement.
How long is the SPCS3 protein?
The Homo sapiens SPCS3 protein (UniProt P61009) is 180 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB P61009 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB P61009 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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