11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2)

About 11-beta-hydroxysteroid dehydrogenase type 2

11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2) is a protein from Homo sapiens identified by UniProt accession P80365, 405 residues long. MolForge cross-references it against 0 known binders and 211 disease associations.

Target properties

Protein name	11-beta-hydroxysteroid dehydrogenase type 2
UniProt accession	P80365
Gene	HSD11B2
Organism	Homo sapiens
Length	405 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (3)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (211)

Diseases linked to this target (Open Targets).

apparent mineralocorticoid excess · score 0.79
gastroesophageal reflux disease · score 0.50
Peptic ulcer · score 0.50
body height · score 0.27
lean body mass · score 0.23
anthropometric measurement · score 0.21
genetic disorder · score 0.19
squamous cell lung carcinoma · score 0.18
whole body water mass · score 0.17
body weights and measures · score 0.14

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P80365-F1	alphafold	PREDICTED	87.41	—

Amino-acid sequence (405 residues)

MERWPWPSGG AWLLVAARAL LQLLRSDLRL GRPLLAALAL LAALDWLCQR LLPPPAALAV LAAAGWIALS RLARPQRLPV ATRAVLITGC DSGFGKETAK KLDSMGFTVL ATVLELNSPG AIELRTCCSP RLRLLQMDLT KPGDISRVLE FTKAHTTSTG LWGLVNNAGH NEVVADAELS PVATFRSCME VNFFGALELT KGLLPLLRSS RGRIVTVGSP AGDMPYPCLG AYGTSKAAVA LLMDTFSCEL LPWGVKVSII QPGCFKTESV RNVGQWEKRK QLLLANLPQE LLQAYGKDYI EHLHGQFLHS LRLAMSDLTP VVDAITDALL AARPRRRYYP GQGLGLMYFI HYYLPEGLRR RFLQAFFISH CLPRALQPGQ PGTTPPQDAA QDPNLSPGPS PAVAR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards