SMAD family member 3 (SMAD3)
Homo sapiens — UniProt P84022
Data last refreshed: (UniProt release unknown)
Key facts
SMAD family member 3 (SMAD3) is a protein from Homo sapiens identified by UniProt accession P84022, 425 residues long. MolForge cross-references it against 0 known binders and 1,046 disease associations.
- UniProt accession: P84022; gene symbol SMAD3.
- Organism: Homo sapiens.
- Length: 425 amino acids.
- Top disease associations (Open Targets): aneurysm-osteoarthritis syndrome, Aneurysm - osteoarthritis syndrome and familial thoracic aortic aneurysm and aortic dissection.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | SMAD family member 3 |
|---|---|
| UniProt accession | P84022 |
| Gene | SMAD3 |
| Organism | Homo sapiens |
| Length | 425 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (1046)
Diseases linked to this target (Open Targets).
- aneurysm-osteoarthritis syndrome · score 0.81
- Aneurysm - osteoarthritis syndrome · score 0.75
- familial thoracic aortic aneurysm and aortic dissection · score 0.71
- Loeys-Dietz syndrome · score 0.66
- Rare disease with thoracic aortic aneurysm and aortic dissection · score 0.57
- colorectal adenocarcinoma · score 0.56
- asthma · score 0.52
- eosinophil count · score 0.51
- coronary artery disease · score 0.50
- heel bone mineral density · score 0.50
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-P84022-F1 | alphafold | PREDICTED | 83.61 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for P84022.
Amino-acid sequence (425 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SMAD3?
The strongest Open Targets associations for SMAD3 are aneurysm-osteoarthritis syndrome, Aneurysm - osteoarthritis syndrome, familial thoracic aortic aneurysm and aortic dissection, Loeys-Dietz syndrome and Rare disease with thoracic aortic aneurysm and aortic dissection.
How long is the SMAD3 protein?
The Homo sapiens SMAD3 protein (UniProt P84022) is 425 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB P84022 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB P84022 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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