Sorbitol dehydrogenase (SORD)
Homo sapiens — UniProt Q00796
Data last refreshed: (UniProt release unknown)
Key facts
Sorbitol dehydrogenase (SORD) is a protein from Homo sapiens identified by UniProt accession Q00796, 357 residues long. MolForge cross-references it against 2 known binders and 212 disease associations.
- UniProt accession: Q00796; gene symbol SORD.
- Organism: Homo sapiens.
- Length: 357 amino acids.
- Top disease associations (Open Targets): neuronopathy, distal hereditary motor, autosomal recessive 8, genetic disorder and Charcot-Marie-Tooth disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Sorbitol dehydrogenase |
|---|---|
| UniProt accession | Q00796 |
| Gene | SORD |
| Organism | Homo sapiens |
| Length | 357 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (212)
Diseases linked to this target (Open Targets).
- neuronopathy, distal hereditary motor, autosomal recessive 8 · score 0.74
- genetic disorder · score 0.41
- Charcot-Marie-Tooth disease · score 0.38
- neuromuscular disease · score 0.34
- peripheral neuropathy · score 0.27
- Red cell distribution width · score 0.23
- mean corpuscular hemoglobin concentration · score 0.18
- hemoglobin measurement · score 0.16
- MODY · score 0.10
- early-onset non-syndromic cataract · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q00796-F1 | alphafold | PREDICTED | 97.98 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q00796.
Amino-acid sequence (357 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SORD?
The strongest Open Targets associations for SORD are neuronopathy, distal hereditary motor, autosomal recessive 8, genetic disorder, Charcot-Marie-Tooth disease, neuromuscular disease and peripheral neuropathy.
How long is the SORD protein?
The Homo sapiens SORD protein (UniProt Q00796) is 357 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q00796 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q00796 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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