Adenylyl cyclase-associated protein 1 (CAP1)
Homo sapiens — UniProt Q01518
Data last refreshed: (UniProt release unknown)
Key facts
Adenylyl cyclase-associated protein 1 (CAP1) is a protein from Homo sapiens identified by UniProt accession Q01518, 475 residues long. MolForge cross-references it against 0 known binders and 45 disease associations.
- UniProt accession: Q01518; gene symbol CAP1.
- Organism: Homo sapiens.
- Length: 475 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, platelet count and lysosomal storage disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Adenylyl cyclase-associated protein 1 |
|---|---|
| UniProt accession | Q01518 |
| Gene | CAP1 |
| Organism | Homo sapiens |
| Length | 475 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (45)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.56
- platelet count · score 0.33
- lysosomal storage disease · score 0.32
- breast adenocarcinoma · score 0.25
- cutaneous melanoma · score 0.13
- mean platelet volume · score 0.11
- neoplasm · score 0.08
- leukocyte count · score 0.05
- chronic obstructive pulmonary disease · score 0.04
- hepatocellular carcinoma · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q01518-F1 | alphafold | PREDICTED | 81.76 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q01518.
Amino-acid sequence (475 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CAP1?
The strongest Open Targets associations for CAP1 are neurodegenerative disease, platelet count, lysosomal storage disease, breast adenocarcinoma and cutaneous melanoma.
How long is the CAP1 protein?
The Homo sapiens CAP1 protein (UniProt Q01518) is 475 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q01518 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q01518 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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