Transcription factor Spi-B (SPIB)
Homo sapiens — UniProt Q01892
Data last refreshed: (UniProt release unknown)
Key facts
Transcription factor Spi-B (SPIB) is a protein from Homo sapiens identified by UniProt accession Q01892, 262 residues long. MolForge cross-references it against 0 known binders and 206 disease associations.
- UniProt accession: Q01892; gene symbol SPIB.
- Organism: Homo sapiens.
- Length: 262 amino acids.
- Top disease associations (Open Targets): primary biliary cirrhosis, biliary liver cirrhosis and coronary artery disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transcription factor Spi-B |
|---|---|
| UniProt accession | Q01892 |
| Gene | SPIB |
| Organism | Homo sapiens |
| Length | 262 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (206)
Diseases linked to this target (Open Targets).
- primary biliary cirrhosis · score 0.31
- biliary liver cirrhosis · score 0.31
- coronary artery disease · score 0.16
- diffuse large B-cell lymphoma · score 0.10
- neoplasm · score 0.10
- cancer · score 0.09
- atrial flutter · score 0.08
- atrial fibrillation · score 0.08
- aneurysmal bone cyst · score 0.08
- hyper-IgM syndrome type 3 · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q01892-F1 | alphafold | PREDICTED | 66.78 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q01892.
Amino-acid sequence (262 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SPIB?
The strongest Open Targets associations for SPIB are primary biliary cirrhosis, biliary liver cirrhosis, coronary artery disease, diffuse large B-cell lymphoma and neoplasm.
How long is the SPIB protein?
The Homo sapiens SPIB protein (UniProt Q01892) is 262 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q01892 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q01892 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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