Transcription factor Sp4 (SP4)
Homo sapiens — UniProt Q02446
Data last refreshed: (UniProt release unknown)
Key facts
Transcription factor Sp4 (SP4) is a protein from Homo sapiens identified by UniProt accession Q02446, 784 residues long. MolForge cross-references it against 0 known binders and 373 disease associations.
- UniProt accession: Q02446; gene symbol SP4.
- Organism: Homo sapiens.
- Length: 784 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, schizophrenia and total cholesterol measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transcription factor Sp4 |
|---|---|
| UniProt accession | Q02446 |
| Gene | SP4 |
| Organism | Homo sapiens |
| Length | 784 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (373)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.49
- schizophrenia · score 0.44
- total cholesterol measurement · score 0.43
- erythrocyte count · score 0.42
- low density lipoprotein cholesterol measurement · score 0.42
- multisite chronic pain · score 0.40
- mean corpuscular volume · score 0.38
- apolipoprotein B measurement · score 0.37
- self reported educational attainment · score 0.37
- cognitive function measurement · score 0.36
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q02446-F1 | alphafold | PREDICTED | 38.82 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q02446.
Amino-acid sequence (784 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SP4?
The strongest Open Targets associations for SP4 are neurodegenerative disease, schizophrenia, total cholesterol measurement, erythrocyte count and low density lipoprotein cholesterol measurement.
How long is the SP4 protein?
The Homo sapiens SP4 protein (UniProt Q02446) is 784 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q02446 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q02446 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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