Transcription factor Sp3 (SP3)
Homo sapiens — UniProt Q02447
Data last refreshed: (UniProt release unknown)
Key facts
Transcription factor Sp3 (SP3) is a protein from Homo sapiens identified by UniProt accession Q02447, 781 residues long. MolForge cross-references it against 0 known binders and 265 disease associations.
- UniProt accession: Q02447; gene symbol SP3.
- Organism: Homo sapiens.
- Length: 781 amino acids.
- Top disease associations (Open Targets): body height, erythrocyte count and appendicular lean mass.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transcription factor Sp3 |
|---|---|
| UniProt accession | Q02447 |
| Gene | SP3 |
| Organism | Homo sapiens |
| Length | 781 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (265)
Diseases linked to this target (Open Targets).
- body height · score 0.38
- erythrocyte count · score 0.33
- appendicular lean mass · score 0.32
- BMI-adjusted waist circumference · score 0.31
- Red cell distribution width · score 0.30
- multiple myeloma · score 0.28
- mean reticulocyte volume · score 0.28
- mean corpuscular volume · score 0.28
- C-reactive protein measurement · score 0.27
- glioblastoma multiforme · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q02447-F1 | alphafold | PREDICTED | 37.87 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q02447.
Amino-acid sequence (781 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SP3?
The strongest Open Targets associations for SP3 are body height, erythrocyte count, appendicular lean mass, BMI-adjusted waist circumference and Red cell distribution width.
How long is the SP3 protein?
The Homo sapiens SP3 protein (UniProt Q02447) is 781 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q02447 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q02447 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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