Elongation factor 1-alpha 2 (EEF1A2)
Homo sapiens — UniProt Q05639
Data last refreshed: (UniProt release unknown)
Key facts
Elongation factor 1-alpha 2 (EEF1A2) is a protein from Homo sapiens identified by UniProt accession Q05639, 463 residues long. MolForge cross-references it against 0 known binders and 270 disease associations.
- UniProt accession: Q05639; gene symbol EEF1A2.
- Organism: Homo sapiens.
- Length: 463 amino acids.
- Top disease associations (Open Targets): undetermined early-onset epileptic encephalopathy, developmental and epileptic encephalopathy and infantile epileptic encephalopathy.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Elongation factor 1-alpha 2 |
|---|---|
| UniProt accession | Q05639 |
| Gene | EEF1A2 |
| Organism | Homo sapiens |
| Length | 463 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (270)
Diseases linked to this target (Open Targets).
- undetermined early-onset epileptic encephalopathy · score 0.74
- developmental and epileptic encephalopathy · score 0.65
- infantile epileptic encephalopathy · score 0.57
- Intellectual disability · score 0.54
- genetic disorder · score 0.51
- autosomal dominant non-syndromic intellectual disability · score 0.37
- complex neurodevelopmental disorder · score 0.37
- electrocardiography · score 0.29
- multiple myeloma · score 0.29
- neoplasm · score 0.29
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q05639-F1 | alphafold | PREDICTED | 88.70 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q05639.
Amino-acid sequence (463 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with EEF1A2?
The strongest Open Targets associations for EEF1A2 are undetermined early-onset epileptic encephalopathy, developmental and epileptic encephalopathy, infantile epileptic encephalopathy, Intellectual disability and genetic disorder.
How long is the EEF1A2 protein?
The Homo sapiens EEF1A2 protein (UniProt Q05639) is 463 amino acids long.
Browse: Targets: E · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q05639 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q05639 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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