MBT domain-containing protein 1 (MBTD1)
Homo sapiens — UniProt Q05BQ5
Data last refreshed: (UniProt release unknown)
Key facts
MBT domain-containing protein 1 (MBTD1) is a protein from Homo sapiens identified by UniProt accession Q05BQ5, 628 residues long. MolForge cross-references it against 1 known binders and 47 disease associations.
- UniProt accession: Q05BQ5; gene symbol MBTD1.
- Organism: Homo sapiens.
- Length: 628 amino acids.
- Top disease associations (Open Targets): BMI-adjusted hip circumference, coronary artery disease and body weight.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | MBT domain-containing protein 1 |
|---|---|
| UniProt accession | Q05BQ5 |
| Gene | MBTD1 |
| Organism | Homo sapiens |
| Length | 628 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (47)
Diseases linked to this target (Open Targets).
- BMI-adjusted hip circumference · score 0.20
- coronary artery disease · score 0.19
- body weight · score 0.14
- age at menarche · score 0.08
- hip circumference · score 0.06
- autosomal recessive spondylocostal dysostosis · score 0.05
- isolated asymptomatic elevation of creatine phosphokinase · score 0.05
- autosomal dominant spondylocostal dysostosis · score 0.05
- pentosuria · score 0.05
- cholesterol-ester transfer protein deficiency · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q05BQ5-F1 | alphafold | PREDICTED | 79.35 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q05BQ5.
Amino-acid sequence (628 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MBTD1?
The strongest Open Targets associations for MBTD1 are BMI-adjusted hip circumference, coronary artery disease, body weight, age at menarche and hip circumference.
How long is the MBTD1 protein?
The Homo sapiens MBTD1 protein (UniProt Q05BQ5) is 628 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q05BQ5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q05BQ5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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