Transcription factor SOX-4 (SOX4)
Homo sapiens — UniProt Q06945
Data last refreshed: (UniProt release unknown)
Key facts
Transcription factor SOX-4 (SOX4) is a protein from Homo sapiens identified by UniProt accession Q06945, 474 residues long. MolForge cross-references it against 0 known binders and 455 disease associations.
- UniProt accession: Q06945; gene symbol SOX4.
- Organism: Homo sapiens.
- Length: 474 amino acids.
- Top disease associations (Open Targets): Coffin-Siris syndrome, neurodegenerative disease and Intellectual disability.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transcription factor SOX-4 |
|---|---|
| UniProt accession | Q06945 |
| Gene | SOX4 |
| Organism | Homo sapiens |
| Length | 474 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (455)
Diseases linked to this target (Open Targets).
- Coffin-Siris syndrome · score 0.68
- neurodegenerative disease · score 0.50
- Intellectual disability · score 0.47
- Global developmental delay · score 0.37
- Abnormal facial shape · score 0.37
- Growth delay · score 0.37
- Clinodactyly of the 5th finger · score 0.37
- syndromic intellectual disability · score 0.37
- developmental disability · score 0.37
- Crohn's disease · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q06945-F1 | alphafold | PREDICTED | 53.19 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q06945.
Amino-acid sequence (474 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SOX4?
The strongest Open Targets associations for SOX4 are Coffin-Siris syndrome, neurodegenerative disease, Intellectual disability, Global developmental delay and Abnormal facial shape.
How long is the SOX4 protein?
The Homo sapiens SOX4 protein (UniProt Q06945) is 474 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q06945 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q06945 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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