Sperm-associated antigen 1 (SPAG1)
Homo sapiens — UniProt Q07617
Data last refreshed: (UniProt release unknown)
Key facts
Sperm-associated antigen 1 (SPAG1) is a protein from Homo sapiens identified by UniProt accession Q07617, 926 residues long. MolForge cross-references it against 0 known binders and 64 disease associations.
- UniProt accession: Q07617; gene symbol SPAG1.
- Organism: Homo sapiens.
- Length: 926 amino acids.
- Top disease associations (Open Targets): primary ciliary dyskinesia, autosomal dominant nocturnal frontal lobe epilepsy 5 and autosomal dominant nocturnal frontal lobe epilepsy.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Sperm-associated antigen 1 |
|---|---|
| UniProt accession | Q07617 |
| Gene | SPAG1 |
| Organism | Homo sapiens |
| Length | 926 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (64)
Diseases linked to this target (Open Targets).
- primary ciliary dyskinesia · score 0.70
- autosomal dominant nocturnal frontal lobe epilepsy 5 · score 0.45
- autosomal dominant nocturnal frontal lobe epilepsy · score 0.45
- Kartagener Syndrome · score 0.33
- basophil count · score 0.21
- lymphocyte percentage of leukocytes · score 0.19
- neutrophil percentage of leukocytes · score 0.18
- genetic disorder · score 0.12
- rheumatoid arthritis · score 0.10
- hematocrit · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q07617-F1 | alphafold | PREDICTED | 73.67 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q07617.
Amino-acid sequence (926 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SPAG1?
The strongest Open Targets associations for SPAG1 are primary ciliary dyskinesia, autosomal dominant nocturnal frontal lobe epilepsy 5, autosomal dominant nocturnal frontal lobe epilepsy, Kartagener Syndrome and basophil count.
How long is the SPAG1 protein?
The Homo sapiens SPAG1 protein (UniProt Q07617) is 926 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q07617 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q07617 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.