Son of sevenless homolog 1 (SOS1)
Homo sapiens — UniProt Q07889
Data last refreshed: (UniProt release unknown)
Key facts
Son of sevenless homolog 1 (SOS1) is a protein from Homo sapiens identified by UniProt accession Q07889, 1333 residues long. MolForge cross-references it against 0 known binders and 263 disease associations.
- UniProt accession: Q07889; gene symbol SOS1.
- Organism: Homo sapiens.
- Length: 1333 amino acids.
- Top disease associations (Open Targets): Noonan syndrome, rasopathy and hereditary gingival fibromatosis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Son of sevenless homolog 1 |
|---|---|
| UniProt accession | Q07889 |
| Gene | SOS1 |
| Organism | Homo sapiens |
| Length | 1333 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (263)
Diseases linked to this target (Open Targets).
- Noonan syndrome · score 0.81
- rasopathy · score 0.66
- hereditary gingival fibromatosis · score 0.65
- cancer · score 0.60
- Noonan syndrome and Noonan-related syndrome · score 0.56
- Abnormality of the cardiovascular system · score 0.54
- bone development disease · score 0.53
- endometrial cancer · score 0.44
- genetic disorder · score 0.44
- lung adenocarcinoma · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q07889-F1 | alphafold | PREDICTED | 76.36 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q07889.
Amino-acid sequence (1333 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SOS1?
The strongest Open Targets associations for SOS1 are Noonan syndrome, rasopathy, hereditary gingival fibromatosis, cancer and Noonan syndrome and Noonan-related syndrome.
How long is the SOS1 protein?
The Homo sapiens SOS1 protein (UniProt Q07889) is 1333 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q07889 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q07889 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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