Son of sevenless homolog 2 (SOS2)
Homo sapiens — UniProt Q07890
Data last refreshed: (UniProt release unknown)
Key facts
Son of sevenless homolog 2 (SOS2) is a protein from Homo sapiens identified by UniProt accession Q07890, 1332 residues long. MolForge cross-references it against 0 known binders and 92 disease associations.
- UniProt accession: Q07890; gene symbol SOS2.
- Organism: Homo sapiens.
- Length: 1332 amino acids.
- Top disease associations (Open Targets): Noonan syndrome, sex hormone-binding globulin measurement and rasopathy.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Son of sevenless homolog 2 |
|---|---|
| UniProt accession | Q07890 |
| Gene | SOS2 |
| Organism | Homo sapiens |
| Length | 1332 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (92)
Diseases linked to this target (Open Targets).
- Noonan syndrome · score 0.78
- sex hormone-binding globulin measurement · score 0.42
- rasopathy · score 0.41
- hypertension · score 0.38
- hemoglobin measurement · score 0.38
- vital capacity · score 0.38
- hydrops fetalis · score 0.37
- body fat percentage · score 0.36
- testosterone measurement · score 0.35
- systolic blood pressure · score 0.35
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q07890-F1 | alphafold | PREDICTED | 73.84 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q07890.
Amino-acid sequence (1332 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SOS2?
The strongest Open Targets associations for SOS2 are Noonan syndrome, sex hormone-binding globulin measurement, rasopathy, hypertension and hemoglobin measurement.
How long is the SOS2 protein?
The Homo sapiens SOS2 protein (UniProt Q07890) is 1332 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q07890 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q07890 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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