Tyrosine-protein kinase ITK/TSK (ITK)
Homo sapiens — UniProt Q08881
Data last refreshed: (UniProt release unknown)
Key facts
Tyrosine-protein kinase ITK/TSK (ITK) is a protein from Homo sapiens identified by UniProt accession Q08881, 620 residues long. MolForge cross-references it against 15 known binders and 474 disease associations.
- UniProt accession: Q08881; gene symbol ITK.
- Organism: Homo sapiens.
- Length: 620 amino acids.
- Approved drugs acting on it (DrugCentral): Ibrutinib and Pazopanib.
- Top disease associations (Open Targets): lymphoproliferative syndrome 1, renal cell carcinoma and sarcoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Tyrosine-protein kinase ITK/TSK |
|---|---|
| UniProt accession | Q08881 |
| Gene | ITK |
| Organism | Homo sapiens |
| Length | 620 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). Approved drug exists
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Approved drugs acting on this target (2)
Approved drugs whose DrugCentral mechanism of action is this protein, most potent first.
Disease associations (474)
Diseases linked to this target (Open Targets).
- lymphoproliferative syndrome 1 · score 0.76
- renal cell carcinoma · score 0.58
- sarcoma · score 0.56
- alopecia areata · score 0.50
- Hodgkins lymphoma · score 0.48
- combined immunodeficiency · score 0.46
- Combined immunodeficiency · score 0.46
- soft tissue sarcoma · score 0.46
- cancer · score 0.45
- genetic disorder · score 0.41
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q08881-F1 | alphafold | PREDICTED | 84.48 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q08881.
Amino-acid sequence (620 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which approved drugs target ITK?
DrugCentral lists 2 approved drugs whose mechanism of action is ITK: Ibrutinib and Pazopanib.
Which diseases are associated with ITK?
The strongest Open Targets associations for ITK are lymphoproliferative syndrome 1, renal cell carcinoma, sarcoma, alopecia areata and Hodgkins lymphoma.
How long is the ITK protein?
The Homo sapiens ITK protein (UniProt Q08881) is 620 amino acids long.
Browse: Targets: I · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q08881 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q08881 — predicted 3D structure (CC BY 4.0)
- DrugCentral — approved drugs and mechanism-of-action links (CC BY-SA 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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