Protein spire homolog 1 (SPIRE1)
Homo sapiens — UniProt Q08AE8
Data last refreshed: (UniProt release unknown)
Key facts
Protein spire homolog 1 (SPIRE1) is a protein from Homo sapiens identified by UniProt accession Q08AE8, 756 residues long. MolForge cross-references it against 0 known binders and 34 disease associations.
- UniProt accession: Q08AE8; gene symbol SPIRE1.
- Organism: Homo sapiens.
- Length: 756 amino acids.
- Top disease associations (Open Targets): erythrocyte count, hemoglobin measurement and hematocrit.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein spire homolog 1 |
|---|---|
| UniProt accession | Q08AE8 |
| Gene | SPIRE1 |
| Organism | Homo sapiens |
| Length | 756 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (34)
Diseases linked to this target (Open Targets).
- erythrocyte count · score 0.37
- hemoglobin measurement · score 0.35
- hematocrit · score 0.30
- red blood cell density measurement · score 0.28
- pulse pressure measurement · score 0.24
- response to vaccine · score 0.18
- Monoamine oxidase A deficiency · score 0.06
- periodontitis · score 0.04
- Crohn's disease · score 0.03
- intelligence · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q08AE8-F1 | alphafold | PREDICTED | 64.04 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q08AE8.
Amino-acid sequence (756 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SPIRE1?
The strongest Open Targets associations for SPIRE1 are erythrocyte count, hemoglobin measurement, hematocrit, red blood cell density measurement and pulse pressure measurement.
How long is the SPIRE1 protein?
The Homo sapiens SPIRE1 protein (UniProt Q08AE8) is 756 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q08AE8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q08AE8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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