SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (SMARCB1)
Homo sapiens — UniProt Q12824
Data last refreshed: (UniProt release unknown)
Key facts
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (SMARCB1) is a protein from Homo sapiens identified by UniProt accession Q12824, 385 residues long. MolForge cross-references it against 0 known binders and 555 disease associations.
- UniProt accession: Q12824; gene symbol SMARCB1.
- Organism: Homo sapiens.
- Length: 385 amino acids.
- Top disease associations (Open Targets): schwannomatosis, familial rhabdoid tumor and Coffin-Siris syndrome.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 |
|---|---|
| UniProt accession | Q12824 |
| Gene | SMARCB1 |
| Organism | Homo sapiens |
| Length | 385 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (555)
Diseases linked to this target (Open Targets).
- schwannomatosis · score 0.71
- familial rhabdoid tumor · score 0.71
- Coffin-Siris syndrome · score 0.69
- schwannoma · score 0.68
- atypical teratoid rhabdoid tumor · score 0.63
- hereditary neoplastic syndrome · score 0.54
- Inherited cancer-predisposing syndrome · score 0.54
- neurodegenerative disease · score 0.51
- meningioma · score 0.44
- malignant rhabdoid tumour · score 0.41
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q12824-F1 | alphafold | PREDICTED | 80.77 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q12824.
Amino-acid sequence (385 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SMARCB1?
The strongest Open Targets associations for SMARCB1 are schwannomatosis, familial rhabdoid tumor, Coffin-Siris syndrome, schwannoma and atypical teratoid rhabdoid tumor.
How long is the SMARCB1 protein?
The Homo sapiens SMARCB1 protein (UniProt Q12824) is 385 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q12824 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q12824 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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