Serine/threonine-protein kinase 4 (STK4)

About Serine/threonine-protein kinase 4

Serine/threonine-protein kinase 4 (STK4) is a protein from Homo sapiens identified by UniProt accession Q13043, 487 residues long. MolForge cross-references it against 10 known binders and 334 disease associations.

Target properties

Protein name	Serine/threonine-protein kinase 4
UniProt accession	Q13043
Gene	STK4
Organism	Homo sapiens
Length	487 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (334)

Diseases linked to this target (Open Targets).

combined immunodeficiency due to STK4 deficiency · score 0.76
combined immunodeficiency · score 0.46
Combined immunodeficiency · score 0.46
severe combined immunodeficiency · score 0.33
neurodegenerative disease · score 0.30
self reported educational attainment · score 0.29
mean platelet volume · score 0.28
bipolar disorder · score 0.26
platelet count · score 0.24
blood protein measurement · score 0.23

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q13043-F1	alphafold	PREDICTED	75.93	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q13043.

Amino-acid sequence (487 residues)

METVQLRNPP RRQLKKLDED SLTKQPEEVF DVLEKLGEGS YGSVYKAIHK ETGQIVAIKQ VPVESDLQEI IKEISIMQQC DSPHVVKYYG SYFKNTDLWI VMEYCGAGSV SDIIRLRNKT LTEDEIATIL QSTLKGLEYL HFMRKIHRDI KAGNILLNTE GHAKLADFGV AGQLTDTMAK RNTVIGTPFW MAPEVIQEIG YNCVADIWSL GITAIEMAEG KPPYADIHPM RAIFMIPTNP PPTFRKPELW SDNFTDFVKQ CLVKSPEQRA TATQLLQHPF VRSAKGVSIL RDLINEAMDV KLKRQESQQR EVDQDDEENS EEDEMDSGTM VRAVGDEMGT VRVASTMTDG ANTMIEHDDT LPSQLGTMVI NAEDEEEEGT MKRRDETMQP AKPSFLEYFE QKEKENQINS FGKSVPGPLK NSSDWKIPQD GDYEFLKSWT VEDLQKRLLA LDPMMEQEIE EIRQKYQSKR QPILDAIEAK KRRQQNF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards