About Serine/threonine-protein kinase 4
Serine/threonine-protein kinase 4 (STK4) is a protein
from Homo sapiens identified by UniProt accession
Q13043, 487 residues long.
MolForge cross-references it against 0 known binders and
334 disease associations.
Target properties
| Protein name | Serine/threonine-protein kinase 4 |
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| UniProt accession | Q13043 |
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| Gene | STK4 |
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| Organism | Homo sapiens |
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| Length | 487 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (10)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (334)
Diseases linked to this target (Open Targets).
- combined immunodeficiency due to STK4 deficiency · score 0.76
- combined immunodeficiency · score 0.46
- Combined immunodeficiency · score 0.46
- severe combined immunodeficiency · score 0.33
- neurodegenerative disease · score 0.30
- self reported educational attainment · score 0.29
- mean platelet volume · score 0.28
- bipolar disorder · score 0.26
- platelet count · score 0.24
- blood protein measurement · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13043-F1 | alphafold | PREDICTED | 75.93 | — |
Amino-acid sequence (487 residues)
METVQLRNPP RRQLKKLDED SLTKQPEEVF DVLEKLGEGS YGSVYKAIHK ETGQIVAIKQ VPVESDLQEI IKEISIMQQC DSPHVVKYYG SYFKNTDLWI VMEYCGAGSV SDIIRLRNKT LTEDEIATIL QSTLKGLEYL HFMRKIHRDI KAGNILLNTE GHAKLADFGV AGQLTDTMAK RNTVIGTPFW MAPEVIQEIG YNCVADIWSL GITAIEMAEG KPPYADIHPM RAIFMIPTNP PPTFRKPELW SDNFTDFVKQ CLVKSPEQRA TATQLLQHPF VRSAKGVSIL RDLINEAMDV KLKRQESQQR EVDQDDEENS EEDEMDSGTM VRAVGDEMGT VRVASTMTDG ANTMIEHDDT LPSQLGTMVI NAEDEEEEGT MKRRDETMQP AKPSFLEYFE QKEKENQINS FGKSVPGPLK NSSDWKIPQD GDYEFLKSWT VEDLQKRLLA LDPMMEQEIE EIRQKYQSKR QPILDAIEAK KRRQQNF
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