About Serine/threonine-protein kinase 3
Serine/threonine-protein kinase 3 (STK3) is a protein
from Homo sapiens identified by UniProt accession
Q13188, 491 residues long.
MolForge cross-references it against 0 known binders and
196 disease associations.
Target properties
| Protein name | Serine/threonine-protein kinase 3 |
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| UniProt accession | Q13188 |
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| Gene | STK3 |
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| Organism | Homo sapiens |
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| Length | 491 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (11)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (196)
Diseases linked to this target (Open Targets).
- erythrocyte count · score 0.17
- gut microbiome measurement · score 0.12
- Age-related cataract · score 0.12
- acute myeloid leukemia · score 0.08
- sarcoma · score 0.06
- familial pancreatic carcinoma · score 0.06
- episodic ataxia type 1 · score 0.06
- Young adult-onset Parkinsonism · score 0.05
- nose morphology measurement · score 0.05
- Spinocerebellar ataxia type 40 · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13188-F1 | alphafold | PREDICTED | 76.35 | — |
Amino-acid sequence (491 residues)
MEQPPAPKSK LKKLSEDSLT KQPEEVFDVL EKLGEGSYGS VFKAIHKESG QVVAIKQVPV ESDLQEIIKE ISIMQQCDSP YVVKYYGSYF KNTDLWIVME YCGAGSVSDI IRLRNKTLIE DEIATILKST LKGLEYLHFM RKIHRDIKAG NILLNTEGHA KLADFGVAGQ LTDTMAKRNT VIGTPFWMAP EVIQEIGYNC VADIWSLGIT SIEMAEGKPP YADIHPMRAI FMIPTNPPPT FRKPELWSDD FTDFVKKCLV KNPEQRATAT QLLQHPFIKN AKPVSILRDL ITEAMEIKAK RHEEQQRELE EEEENSDEDE LDSHTMVKTS VESVGTMRAT STMSEGAQTM IEHNSTMLES DLGTMVINSE DEEEEDGTMK RNATSPQVQR PSFMDYFDKQ DFKNKSHENC NQNMHEPFPM SKNVFPDNWK VPQDGDFDFL KNLSLEELQM RLKALDPMME REIEELRQRY TAKRQPILDA MDAKKRRQQN F
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