Serine/threonine-protein kinase 3 (STK3)

About Serine/threonine-protein kinase 3

Serine/threonine-protein kinase 3 (STK3) is a protein from Homo sapiens identified by UniProt accession Q13188, 491 residues long. MolForge cross-references it against 11 known binders and 196 disease associations.

Target properties

Protein name	Serine/threonine-protein kinase 3
UniProt accession	Q13188
Gene	STK3
Organism	Homo sapiens
Length	491 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (196)

Diseases linked to this target (Open Targets).

erythrocyte count · score 0.17
gut microbiome measurement · score 0.12
Age-related cataract · score 0.12
acute myeloid leukemia · score 0.08
sarcoma · score 0.06
familial pancreatic carcinoma · score 0.06
episodic ataxia type 1 · score 0.06
Young adult-onset Parkinsonism · score 0.05
nose morphology measurement · score 0.05
Spinocerebellar ataxia type 40 · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q13188-F1	alphafold	PREDICTED	76.35	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q13188.

Amino-acid sequence (491 residues)

MEQPPAPKSK LKKLSEDSLT KQPEEVFDVL EKLGEGSYGS VFKAIHKESG QVVAIKQVPV ESDLQEIIKE ISIMQQCDSP YVVKYYGSYF KNTDLWIVME YCGAGSVSDI IRLRNKTLIE DEIATILKST LKGLEYLHFM RKIHRDIKAG NILLNTEGHA KLADFGVAGQ LTDTMAKRNT VIGTPFWMAP EVIQEIGYNC VADIWSLGIT SIEMAEGKPP YADIHPMRAI FMIPTNPPPT FRKPELWSDD FTDFVKKCLV KNPEQRATAT QLLQHPFIKN AKPVSILRDL ITEAMEIKAK RHEEQQRELE EEEENSDEDE LDSHTMVKTS VESVGTMRAT STMSEGAQTM IEHNSTMLES DLGTMVINSE DEEEEDGTMK RNATSPQVQR PSFMDYFDKQ DFKNKSHENC NQNMHEPFPM SKNVFPDNWK VPQDGDFDFL KNLSLEELQM RLKALDPMME REIEELRQRY TAKRQPILDA MDAKKRRQQN F

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards