Nuclear body protein SP140 (SP140)
Homo sapiens — UniProt Q13342
Data last refreshed: (UniProt release unknown)
Key facts
Nuclear body protein SP140 (SP140) is a protein from Homo sapiens identified by UniProt accession Q13342, 867 residues long. MolForge cross-references it against 0 known binders and 115 disease associations.
- UniProt accession: Q13342; gene symbol SP140.
- Organism: Homo sapiens.
- Length: 867 amino acids.
- Top disease associations (Open Targets): Hepatic veno-occlusive disease - immunodeficiency, hepatic veno-occlusive disease-immunodeficiency syndrome and multiple myeloma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Nuclear body protein SP140 |
|---|---|
| UniProt accession | Q13342 |
| Gene | SP140 |
| Organism | Homo sapiens |
| Length | 867 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (115)
Diseases linked to this target (Open Targets).
- Hepatic veno-occlusive disease - immunodeficiency · score 0.54
- hepatic veno-occlusive disease-immunodeficiency syndrome · score 0.54
- multiple myeloma · score 0.37
- eosinophil count · score 0.35
- Crohn's disease · score 0.35
- chronic lymphocytic leukemia · score 0.34
- multiple sclerosis · score 0.31
- eosinophil percentage of leukocytes · score 0.29
- ulcerative colitis · score 0.23
- inflammatory bowel disease · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q13342-F1 | alphafold | PREDICTED | 56.99 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q13342.
Amino-acid sequence (867 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SP140?
The strongest Open Targets associations for SP140 are Hepatic veno-occlusive disease - immunodeficiency, hepatic veno-occlusive disease-immunodeficiency syndrome, multiple myeloma, eosinophil count and Crohn's disease.
How long is the SP140 protein?
The Homo sapiens SP140 protein (UniProt Q13342) is 867 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q13342 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q13342 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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