Scaffold protein ILK (ILK)
Homo sapiens — UniProt Q13418
Data last refreshed: (UniProt release unknown)
Key facts
Scaffold protein ILK (ILK) is a protein from Homo sapiens identified by UniProt accession Q13418, 452 residues long. MolForge cross-references it against 2 known binders and 374 disease associations.
- UniProt accession: Q13418; gene symbol ILK.
- Organism: Homo sapiens.
- Length: 452 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, breast adenocarcinoma and familial hypertrophic cardiomyopathy.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Scaffold protein ILK |
|---|---|
| UniProt accession | Q13418 |
| Gene | ILK |
| Organism | Homo sapiens |
| Length | 452 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (374)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.47
- breast adenocarcinoma · score 0.23
- familial hypertrophic cardiomyopathy · score 0.19
- endometrial cancer · score 0.18
- Abnormality of the cardiovascular system · score 0.15
- dilated cardiomyopathy · score 0.12
- Prolonged QT interval · score 0.12
- neoplasm · score 0.11
- head and neck squamous cell carcinoma · score 0.10
- melanoma · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q13418-F1 | alphafold | PREDICTED | 88.17 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q13418.
Amino-acid sequence (452 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ILK?
The strongest Open Targets associations for ILK are neurodegenerative disease, breast adenocarcinoma, familial hypertrophic cardiomyopathy, endometrial cancer and Abnormality of the cardiovascular system.
How long is the ILK protein?
The Homo sapiens ILK protein (UniProt Q13418) is 452 amino acids long.
Browse: Targets: I · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q13418 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q13418 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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