Alpha-1-syntrophin (SNTA1)
Homo sapiens — UniProt Q13424
Data last refreshed: (UniProt release unknown)
Key facts
Alpha-1-syntrophin (SNTA1) is a protein from Homo sapiens identified by UniProt accession Q13424, 505 residues long. MolForge cross-references it against 0 known binders and 64 disease associations.
- UniProt accession: Q13424; gene symbol SNTA1.
- Organism: Homo sapiens.
- Length: 505 amino acids.
- Top disease associations (Open Targets): Romano-Ward syndrome, long QT syndrome 12 and Prolonged QT interval.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Alpha-1-syntrophin |
|---|---|
| UniProt accession | Q13424 |
| Gene | SNTA1 |
| Organism | Homo sapiens |
| Length | 505 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (64)
Diseases linked to this target (Open Targets).
- Romano-Ward syndrome · score 0.67
- long QT syndrome 12 · score 0.67
- Prolonged QT interval · score 0.35
- atrial fibrillation · score 0.27
- familial long QT syndrome · score 0.20
- Abnormality of the cardiovascular system · score 0.19
- long QT syndrome 1 · score 0.15
- Duchenne muscular dystrophy · score 0.12
- Becker muscular dystrophy · score 0.12
- sick sinus syndrome · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q13424-F1 | alphafold | PREDICTED | 78.88 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q13424.
Amino-acid sequence (505 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SNTA1?
The strongest Open Targets associations for SNTA1 are Romano-Ward syndrome, long QT syndrome 12, Prolonged QT interval, atrial fibrillation and familial long QT syndrome.
How long is the SNTA1 protein?
The Homo sapiens SNTA1 protein (UniProt Q13424) is 505 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q13424 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q13424 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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