Beta-2-syntrophin (SNTB2)
Homo sapiens — UniProt Q13425
Data last refreshed: (UniProt release unknown)
Key facts
Beta-2-syntrophin (SNTB2) is a protein from Homo sapiens identified by UniProt accession Q13425, 540 residues long. MolForge cross-references it against 0 known binders and 43 disease associations.
- UniProt accession: Q13425; gene symbol SNTB2.
- Organism: Homo sapiens.
- Length: 540 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, diastolic blood pressure and Parkinson disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Beta-2-syntrophin |
|---|---|
| UniProt accession | Q13425 |
| Gene | SNTB2 |
| Organism | Homo sapiens |
| Length | 540 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (43)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.31
- diastolic blood pressure · score 0.26
- Parkinson disease · score 0.18
- multiple sclerosis · score 0.18
- Alzheimer disease · score 0.18
- lysosomal storage disease · score 0.18
- alcohol consumption measurement · score 0.18
- handedness · score 0.13
- body fat percentage · score 0.09
- self reported educational attainment · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q13425-F1 | alphafold | PREDICTED | 78.66 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q13425.
Amino-acid sequence (540 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SNTB2?
The strongest Open Targets associations for SNTB2 are neurodegenerative disease, diastolic blood pressure, Parkinson disease, multiple sclerosis and Alzheimer disease.
How long is the SNTB2 protein?
The Homo sapiens SNTB2 protein (UniProt Q13425) is 540 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q13425 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q13425 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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