SMAD family member 4 (SMAD4)
Homo sapiens — UniProt Q13485
Data last refreshed: (UniProt release unknown)
Key facts
SMAD family member 4 (SMAD4) is a protein from Homo sapiens identified by UniProt accession Q13485, 552 residues long. MolForge cross-references it against 0 known binders and 856 disease associations.
- UniProt accession: Q13485; gene symbol SMAD4.
- Organism: Homo sapiens.
- Length: 552 amino acids.
- Top disease associations (Open Targets): juvenile polyposis syndrome, juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome and Myhre syndrome.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | SMAD family member 4 |
|---|---|
| UniProt accession | Q13485 |
| Gene | SMAD4 |
| Organism | Homo sapiens |
| Length | 552 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (856)
Diseases linked to this target (Open Targets).
- juvenile polyposis syndrome · score 0.81
- juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome · score 0.81
- Myhre syndrome · score 0.81
- pancreatic adenocarcinoma · score 0.70
- pancreatic neoplasm · score 0.69
- pancreatic carcinoma · score 0.67
- generalized juvenile polyposis/juvenile polyposis coli · score 0.65
- familial pancreatic carcinoma · score 0.65
- familial thoracic aortic aneurysm and aortic dissection · score 0.65
- colorectal adenocarcinoma · score 0.65
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q13485-F1 | alphafold | PREDICTED | 73.38 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q13485.
Amino-acid sequence (552 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SMAD4?
The strongest Open Targets associations for SMAD4 are juvenile polyposis syndrome, juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome, Myhre syndrome, pancreatic adenocarcinoma and pancreatic neoplasm.
How long is the SMAD4 protein?
The Homo sapiens SMAD4 protein (UniProt Q13485) is 552 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q13485 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q13485 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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