DNA repair-scaffolding protein (SPIDR)
Homo sapiens — UniProt Q14159
Data last refreshed: (UniProt release unknown)
Key facts
DNA repair-scaffolding protein (SPIDR) is a protein from Homo sapiens identified by UniProt accession Q14159, 915 residues long. MolForge cross-references it against 0 known binders and 61 disease associations.
- UniProt accession: Q14159; gene symbol SPIDR.
- Organism: Homo sapiens.
- Length: 915 amino acids.
- Top disease associations (Open Targets): ovarian dysgenesis 9, neurodegenerative disease and genetic non-acquired premature ovarian failure.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | DNA repair-scaffolding protein |
|---|---|
| UniProt accession | Q14159 |
| Gene | SPIDR |
| Organism | Homo sapiens |
| Length | 915 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (61)
Diseases linked to this target (Open Targets).
- ovarian dysgenesis 9 · score 0.52
- neurodegenerative disease · score 0.42
- genetic non-acquired premature ovarian failure · score 0.42
- 46,XX gonadal dysgenesis · score 0.37
- monocyte count · score 0.35
- reticulocyte count · score 0.30
- eosinophil count · score 0.30
- heel bone mineral density · score 0.28
- blood protein measurement · score 0.28
- breast adenocarcinoma · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q14159-F1 | alphafold | PREDICTED | 61.98 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q14159.
Amino-acid sequence (915 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SPIDR?
The strongest Open Targets associations for SPIDR are ovarian dysgenesis 9, neurodegenerative disease, genetic non-acquired premature ovarian failure, 46,XX gonadal dysgenesis and monocyte count.
How long is the SPIDR protein?
The Homo sapiens SPIDR protein (UniProt Q14159) is 915 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q14159 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q14159 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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