Structural maintenance of chromosomes protein 1A (SMC1A)
Homo sapiens — UniProt Q14683
Data last refreshed: (UniProt release unknown)
Key facts
Structural maintenance of chromosomes protein 1A (SMC1A) is a protein from Homo sapiens identified by UniProt accession Q14683, 1233 residues long. MolForge cross-references it against 1 known binders and 260 disease associations.
- UniProt accession: Q14683; gene symbol SMC1A.
- Organism: Homo sapiens.
- Length: 1233 amino acids.
- Top disease associations (Open Targets): developmental and epileptic encephalopathy, Cornelia de Lange syndrome and genetic disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Structural maintenance of chromosomes protein 1A |
|---|---|
| UniProt accession | Q14683 |
| Gene | SMC1A |
| Organism | Homo sapiens |
| Length | 1233 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (260)
Diseases linked to this target (Open Targets).
- developmental and epileptic encephalopathy · score 0.70
- Cornelia de Lange syndrome · score 0.67
- genetic disorder · score 0.53
- Epileptic encephalopathy · score 0.50
- Wiedemann-Steiner syndrome · score 0.42
- Microcephaly · score 0.41
- Global developmental delay · score 0.37
- semilobar holoprosencephaly · score 0.37
- atypical Rett syndrome · score 0.37
- X-linked complex neurodevelopmental disorder · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q14683-F1 | alphafold | PREDICTED | 82.81 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q14683.
Amino-acid sequence (1233 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SMC1A?
The strongest Open Targets associations for SMC1A are developmental and epileptic encephalopathy, Cornelia de Lange syndrome, genetic disorder, Epileptic encephalopathy and Wiedemann-Steiner syndrome.
How long is the SMC1A protein?
The Homo sapiens SMC1A protein (UniProt Q14683) is 1233 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q14683 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q14683 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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