Single-pass membrane and coiled-coil domain-containing protein 1 (SMCO1)
Homo sapiens — UniProt Q147U7
Data last refreshed: (UniProt release unknown)
Key facts
Single-pass membrane and coiled-coil domain-containing protein 1 (SMCO1) is a protein from Homo sapiens identified by UniProt accession Q147U7, 214 residues long. MolForge cross-references it against 0 known binders and 10 disease associations.
- UniProt accession: Q147U7; gene symbol SMCO1.
- Organism: Homo sapiens.
- Length: 214 amino acids.
- Top disease associations (Open Targets): sex hormone-binding globulin measurement, self reported educational attainment and systolic blood pressure.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Single-pass membrane and coiled-coil domain-containing protein 1 |
|---|---|
| UniProt accession | Q147U7 |
| Gene | SMCO1 |
| Organism | Homo sapiens |
| Length | 214 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (10)
Diseases linked to this target (Open Targets).
- sex hormone-binding globulin measurement · score 0.03
- self reported educational attainment · score 0.02
- systolic blood pressure · score 0.02
- total blood protein measurement · score 0.02
- diastolic blood pressure · score 0.02
- mean corpuscular volume · score 0.02
- Tetralogy of Fallot · score 0.01
- oral squamous cell carcinoma · score 0.00
- breast cancer · score 0.00
- triple-negative breast cancer · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q147U7-F1 | alphafold | PREDICTED | 89.25 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q147U7.
Amino-acid sequence (214 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SMCO1?
The strongest Open Targets associations for SMCO1 are sex hormone-binding globulin measurement, self reported educational attainment, systolic blood pressure, total blood protein measurement and diastolic blood pressure.
How long is the SMCO1 protein?
The Homo sapiens SMCO1 protein (UniProt Q147U7) is 214 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q147U7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q147U7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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