Sodium/hydrogen exchanger 5 (SLC9A5)
Homo sapiens — UniProt Q14940
Data last refreshed: (UniProt release unknown)
Key facts
Sodium/hydrogen exchanger 5 (SLC9A5) is a protein from Homo sapiens identified by UniProt accession Q14940, 896 residues long. MolForge cross-references it against 1 known binders and 64 disease associations.
- UniProt accession: Q14940; gene symbol SLC9A5.
- Organism: Homo sapiens.
- Length: 896 amino acids.
- Approved drugs acting on it (DrugCentral): Amiloride.
- Top disease associations (Open Targets): neurodegenerative disease, cutaneous melanoma and lung adenocarcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Sodium/hydrogen exchanger 5 |
|---|---|
| UniProt accession | Q14940 |
| Gene | SLC9A5 |
| Organism | Homo sapiens |
| Length | 896 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). Approved drug exists
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Approved drugs acting on this target (1)
Approved drugs whose DrugCentral mechanism of action is this protein, most potent first.
Disease associations (64)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.45
- cutaneous melanoma · score 0.13
- lung adenocarcinoma · score 0.12
- reticulocyte measurement · score 0.09
- Blackfan-Diamond anemia · score 0.08
- hereditary persistence of fetal hemoglobin-sickle cell disease syndrome · score 0.08
- alpha thalassemia-intellectual disability syndrome type 1 · score 0.07
- Alpha-thalassemia - intellectual disability syndrome linked to chromosome 16 · score 0.07
- reticulocyte count · score 0.06
- delta-beta-thalassemia · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q14940-F1 | alphafold | PREDICTED | 64.16 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q14940.
Amino-acid sequence (896 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which approved drugs target SLC9A5?
DrugCentral lists 1 approved drug whose mechanism of action is SLC9A5: Amiloride.
Which diseases are associated with SLC9A5?
The strongest Open Targets associations for SLC9A5 are neurodegenerative disease, cutaneous melanoma, lung adenocarcinoma, reticulocyte measurement and Blackfan-Diamond anemia.
How long is the SLC9A5 protein?
The Homo sapiens SLC9A5 protein (UniProt Q14940) is 896 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q14940 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q14940 — predicted 3D structure (CC BY 4.0)
- DrugCentral — approved drugs and mechanism-of-action links (CC BY-SA 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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