Calcium-activated chloride channel regulator 4 (CLCA4)
Homo sapiens — UniProt Q14CN2
Data last refreshed: (UniProt release unknown)
Key facts
Calcium-activated chloride channel regulator 4 (CLCA4) is a protein from Homo sapiens identified by UniProt accession Q14CN2, 919 residues long. MolForge cross-references it against 0 known binders and 54 disease associations.
- UniProt accession: Q14CN2; gene symbol CLCA4.
- Organism: Homo sapiens.
- Length: 919 amino acids.
- Top disease associations (Open Targets): cystic fibrosis, glioblastoma multiforme and breast adenocarcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Calcium-activated chloride channel regulator 4 |
|---|---|
| UniProt accession | Q14CN2 |
| Gene | CLCA4 |
| Organism | Homo sapiens |
| Length | 919 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (54)
Diseases linked to this target (Open Targets).
- cystic fibrosis · score 0.38
- glioblastoma multiforme · score 0.18
- breast adenocarcinoma · score 0.16
- head and neck squamous cell carcinoma · score 0.12
- neoplasm · score 0.09
- urinary bladder carcinoma · score 0.08
- hepatocellular carcinoma · score 0.08
- colorectal carcinoma · score 0.07
- colorectal cancer · score 0.06
- diabetes mellitus · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q14CN2-F1 | alphafold | PREDICTED | 89.31 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q14CN2.
Amino-acid sequence (919 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CLCA4?
The strongest Open Targets associations for CLCA4 are cystic fibrosis, glioblastoma multiforme, breast adenocarcinoma, head and neck squamous cell carcinoma and neoplasm.
How long is the CLCA4 protein?
The Homo sapiens CLCA4 protein (UniProt Q14CN2) is 919 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q14CN2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q14CN2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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