Transmembrane protein 132B (TMEM132B)
Homo sapiens — UniProt Q14DG7
Data last refreshed: (UniProt release unknown)
Key facts
Transmembrane protein 132B (TMEM132B) is a protein from Homo sapiens identified by UniProt accession Q14DG7, 1078 residues long. MolForge cross-references it against 0 known binders and 37 disease associations.
- UniProt accession: Q14DG7; gene symbol TMEM132B.
- Organism: Homo sapiens.
- Length: 1078 amino acids.
- Top disease associations (Open Targets): protein measurement, smoking status measurement and attention deficit hyperactivity disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transmembrane protein 132B |
|---|---|
| UniProt accession | Q14DG7 |
| Gene | TMEM132B |
| Organism | Homo sapiens |
| Length | 1078 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (37)
Diseases linked to this target (Open Targets).
- protein measurement · score 0.33
- smoking status measurement · score 0.32
- attention deficit hyperactivity disorder · score 0.31
- smoking behavior · score 0.31
- substance abuse · score 0.31
- antisocial behaviour measurement · score 0.31
- brain measurement · score 0.30
- triglyceride measurement · score 0.28
- sleep duration · score 0.28
- childhood trauma measurement · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q14DG7-F1 | alphafold | PREDICTED | 69.97 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q14DG7.
Amino-acid sequence (1078 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TMEM132B?
The strongest Open Targets associations for TMEM132B are protein measurement, smoking status measurement, attention deficit hyperactivity disorder, smoking behavior and substance abuse.
How long is the TMEM132B protein?
The Homo sapiens TMEM132B protein (UniProt Q14DG7) is 1078 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q14DG7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q14DG7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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